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The compound was first characterized by Billon, Sitaula, Banerjee, and colleagues from the Burris laboratory at Saint Louis University, published in ACS Chemical Biology in 2023, as a pan-agonist of ERRα, ERRβ, and ERRγ — the three members of the estrogen-related receptor subfamily

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147 By integrating these molecular insights with biomechanical and clinical data, researchers can develop comprehensive models that predict ACL injury risk based on tibial slope and other anatomical factors