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GABAA-mediated slow synaptic inhibition is significantly reduced in granule neurons of the dentate gyrus of aged AD mice compared to wild-type controls and young AD mice, explaining the change in excitatory-inhibitory balance [147]

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• • T cell transfer model (IL-23 driven): Transfer of naive CD4 + CD45RB hi T cells into immunodeficient mice results in IL-23-dependent colonic inflammation which mimics the T cell-driven immune response against intestinal antigens observed in human IBD ( 106 )