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The protein is widely expressed in all tissues, with the most abundant expression in liver and placenta [11]

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The core components of COPD therapy include combinations of bronchodilators, such as long-acting β2-agonists (LABA) and long-acting anti-muscarinic agonists (LAMA), alongside corticosteroids (inhaled or oral) antibiotics 6 mucolytics, and macrolides for patients with frequent exacerbations