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A 2003 prospective cohort study by Khavinson and Morozov found that epithalon had the following effects when administered to a sample of 266 adults over the age of 60 [9]: Decreased incidence of ischemic heart disease Decreased incidence of hypertension disease Lowered rates of deforming osteoarthritis and osteoporosis More recently, a 2020 study by Khavinson et al