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Critically, conditionally essential nutrients, when supplied exogenously, correct a clinically relevant outcome measure (Reference Grimble99,Reference Mischley100) In the context of clinical nutrition, Grimble in 1993 proposed five criteria to define conditionally essential nutrients in humans, whereby their deficiency results in either: failure to maintain growth or nitrogen balance, organ dysfunction, delayed recovery, metabolic or clinical abnormalities (Reference Grimble99)
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Cereblon designation derives from its high expression in the cerebellum, its importance in mental development, as well as its highly conserved ATP-dependent Lon domain 37