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Serotonin depletion aggravates APAP-induced liver injury in wild type mice and serotonin reloading mitigates hepatotoxicity in TPH1-/- mice To further validate the role of 5-HT in APAP-induced liver injury, wild type mice were treated with the PCPA before APAP challenge, which has been shown to be a powerful TPH1 enzyme inhibitor 25,29

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In T1D, IGF-1 synthesis is significantly reduced, while in T2D various deviations arise in IGF-1 actions such as sensitization to its mitogenic actions in some target tissues, including liver, pancreas, and peripheral tissues [42]