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[DOI] [PubMed] [Google Scholar] 22.Lucke VM, Davies JD

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In addition, it has been shown that 5-azacitidine (5-aza), a DNA hypomethylating agent, has synergistic effects when given with a topoisomerase 1 inhibitor, irinotecan, for the treatment of CRC [99], further complicating the role of DNA methylation in CRC