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IL-6 signaling is mediated by two main pathways: classic signaling through membrane-bound IL-6 receptors (IL-6R) on immune cells, and trans-signaling through soluble IL-6R, which can activate cells lacking IL-6R via glycoprotein 130 (gp130) [27]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 481.Dai W, Wang G, Chwa J, Oh ME, Abeywardana T, Yang Y, Wang QA, Jiang L