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Most peptides above roughly 500 Da are poor oral candidates because gastric proteases cleave peptide bonds and the acidic environment (pH roughly 1.5 to 3.5 fasting) denatures secondary structure

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doi: 10.1016/S0140-6736(11)60096-2 548 WhitePDGoldsmithKJohnsonALChalderTSharpeM

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