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In rats assessed 2–4 weeks after ischemic injury, minocycline improved perfusion, reduced BBB permeability with higher levels of TJ proteins, and decreased the frequency of proinflammatory microglia, shifting their activation to an M2-like, or anti-inflammatory, phenotype with upregulation of transforming growth factor beta (TGF- β) and IL-10 and decreased TNF-α and IL-1β (Yang et al., 2015)

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Iodine intake as a determinant of thyroid disorders in populations