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Furthermore, the NNMT SNP rs694539 increases risk of acute lymphoblastic leukemia ( NNMT is expressed mainly in the liver and adipose tissue, and a small amount of NNMT can be detected in the kidney, lung, skeletal muscle, and the heart ( NNMT expression is altered in metabolic diseases such as obesity and cirrhosis ( Association Between NNMT Expression and Poor Cancer Prognosis Considering that NNMT is elevated in various cancers, most studies on NNMT have focused on its early diagnostic role ( In addition to being used in early diagnosis, NNMT is also related to poor prognosis
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Bottle Size:250 mL
We summarized the known posttranslational modifications and sites on NNMT in Table 2, which were obtained from the iPTMnet Website ( The interactome of NNMT We examined the interacting proteins of NNMT using the STRING database [35] ( showing that NNMT interacts with the following proteins including caveolae-associated protein 1 (PTRF), aldehyde oxidase (AOX1), epidermal growth factor receptor (EGFR), four and a half LIM domains protein 2 (FHL2), nicotinamide phosphoribosyltransferase (NAMPT), NAD-dependent protein deacetylase sirtuin 1-7 (SIRT1-7), ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (BST1), and ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) in human and mice
