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However, there are very limited number of CDM reference spectra and there is no specialized spectral library for CDMs so far

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Since HBsAg is almost entirely derived from SVP [9], establishing a functional cure of HBV infection requires not only clearing SVP from the blood but removing the SVP producing capacity in the liver by the silencing of cccDNA and the removal of hepatocytes with integrated HBV DNA [14,15]