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Ependymal cells, as BBB components, downregulate tight junction proteins (e.g., zonula occludens-1 (ZO-1)) under inflammatory (TNF-α) or α-syn attack, allowing peripheral pro-inflammatory cytokines (e.g., IL-6), iron/copper ions, and immune cells (e.g., macrophages) to infiltrate the brain parenchyma [272]

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The science suggests that it is one of the most effective ways to support your body's antioxidant levels orally