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Observed Orange Book normalized TE history# Normalized TE history page 1 of 2 · 42 observed states

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Several possibilities have been proposed that may explain this phenomenon, including failure to use optimum IGF-I doses, inadequate access of the exogenous IGF-I to its tissue receptor, insufficient serum concentrations of binding proteins to maximize IGF-I activity, or the possibility that growth hormone and IGF-I may have independent and overlapping effects