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Indeed, elevated homocysteine is now recognized as a strong risk factor for cognitive impairment and dementia, including Alzheimer’s disease (66-68)

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In further embodiments, the invention encompasses a method of providing muscular therapy by contacting a cell expressing NNMT with one or more cations chosen from 1c, 1f, 1l, 1m, 2j, 2k, 2l, 2m, 2aa, 1c′, 1f′, 1l′, 1m′, 2j′, 2k′, 2l′, 2m′, and 2aa′

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