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where, Parameters are defined exactly as previously described 6 , i.e., respectively, A and B are agonist and modulator concentrations, K A and K B are agonist and modulator binding affinity (dissociation constant) to the inactive receptor state, α and β are modifiers to affinity and efficacy, χ, τ A , τ B are the efficacy parameters for receptor alone, agonist-bound receptor and modulator-bound receptor

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& Ye, B.) 79–115 (Springer, 2014)