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These studies should assess the acute and chronic effects of ketamine on glucose homeostasis, evaluate cognitive outcomes relative to baseline neurovascular health, examine drug–drug interactions with commonly prescribed antidiabetic and antihypertensive agents, and determine long-term renal and cardiovascular outcomes given ketamine’s elimination profile and diabetes-related organ vulnerability

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To provide a robust summary of relative treatment effects, an analysis was conducted to assess the degree of heterogeneity between the trials included in the network in terms of participants, study design, interventions and outcomes (full analysis available in supplementary material) [22]