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A study on rats showed that the ROS could activate the MAPK pathway to trigger autophagy in NP cells of rat and to modulate the generation of TNF- α , matrix metalloproteinase-3 (MMP-3), cyclooxygenase-2, and aggrecan expression in AF cells of rat [93, 94]

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Transplantation of MSC elicited up-regulation of brain-derived neurotrophic factor (BDNF), epidermal growth factor (EGF), fibroblast growth factor 2 (FGF2), insulin-like growth factor 1 (IGF1) and vascular endothelial growth factor (VEGF)