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Inflammatory cytokines such as IL-6 can upregulate hepcidin transcription in the liver through Janus kinase signaling and the transcriptional activator 3 pathway, thereby inhibiting iron absorption mediated by FPN in intestinal epithelial cells, leading to decreased serum iron levels and intracellular iron overload in macrophages

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Considering that sleep patterns are regulated by melatonin, Epitalon therapy evidently plays a crucial role in enhancing sleep quality