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MITOCHONDRIAL REACTIVE OXYGEN AND REACTIVE NITROGEN SPECIES The main characteristic of mitochondrial dysfunction induced by APAP adducts is increased generation of ROS such as superoxide31, as well as peroxynitrite32, which can modify proteins by nitration of their tyrosine residues33 (Fig

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While it has long been studied for its role in the body's natural antioxidant defense system, glutathione gained popularity in topical skincare formulations as researchers and skincare brands explored its potential to complement other brightening ingredients when applied directly to the skin