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Hypothesising that decreased macrophage viability in an oxidative environment could be a contributing factor to the pathophysiology of CD, we found that monocyte-derived macrophages from individuals with active CD (but not those in clinical disease remission) have increased sensitivity to cell death induced by H 2 O 2

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Nucleic Acids Res (2009) 37:7024–38.10.1093/nar/gkp747 45 TallackMRWhitingtonTYuenWSWainwrightENKeysJRGardinerBBet alA global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells